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What should be monitored when taking methotrexate? A methotrexate test is typically requested at 24 hours, 48 hours, and at 72 hours as needed after high-dose methotrexate is administered. Tests to monitor blood cell counts and kidney and liver function are also requested at regular intervals during methotrexate therapy.
Does methotrexate cause weight gain or loss? Weight gain was seen at 6 months among users of methotrexate, prednisone, and TNFi. On average, prednisone-treated patients had significantly more weight gain, while leflunomide-treated patients demonstrated weight loss.
Does prednisone shorten your life? Mean duration of use was 6.9 years with a mean dose of 8.0 mg/day. Prednisone was eventually stopped in 34% of patients. Life expectancy and causes of death were similar in both groups. As expected, adverse events, notably cataracts and fractures, were observed more often in the prednisone group.
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